![]() For example, we can take cells from patients with and without a disease and compare their morphology. This snapshot is called a profile, and once it has been extracted from a cell, we can compare and contrast that cell with other cells, which may have been treated with different drugs, for example.Įureka: Can you provide an example of how these tools have accelerated drug development?ĪC: This ability to quantitatively match cells based on their image-based profile is deceptively simple but there are so many applications in drug discovery. How does that work?ĪC: Images contain far more information about the state of cells than is typically measured by biologists-in fact, more than can even be detected by eye! We aim to capture that information by measuring a huge variety of properties of each cell in each image, producing a quantitative snapshot of the cell's state. ![]() A cancer researcher might use CellProfiler Analyst to detect cells that have a metastatic appearance by providing a few dozen example images of cells that are metastatic and non-metastatic.Įureka: You have also developed a unique way of mining and measuring the myriad features of a cell, called image-based profiling. For example, a neuroscientist might use CellProfiler to identify and count the number of synapses per cell in an image. CellProfiler Analyst allows biologists to use machine learning to train a classifier that can recognize cells that have a particular appearance, or phenotype, of interest. What is the difference between them?ĪC: CellProfiler automatically identifies cells in images and measures their properties. Here are her emailed responses.Įureka: Your lab developed the image software tools CellProfiler in 2005 and later CellProfiler Analyst. Carpenter as part of its series on AI in Drug Discovery. Today, the team’s open-source CellProfiler software is used by thousands of biologists worldwide. She decided to write her own software code to solve the imaging problems, and that code eventually became CellProfiler. ![]() When she was doing her post-doctoral work at MIT’s Whitehead Institute for Biomedical Research, she encountered a bottleneck in the processing of cell images while measuring the size of Drosophila fruit fly cells. Her research group develops algorithms and strategies for large-scale experiments involving images. Part four in our series on AI in Drug Discovery.Īnne Carpenter, an Institute Scientist at the Broad Institute of Harvard and MIT, is a pioneer in image-based profiling, the extraction of rich, unbiased information from images for a number of important applications in drug discovery and functional genomics. How a software tool for image analysis is helping to accelerate drug discovery. ![]()
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But it will be a good starting point, from which you can start adjusting things, choosing a new built-in (or third-party) design, bringing in any pieces that the extractor may have missed, and adding new Sandvox objects to your pages. Also your rapid response to requests is second to none and I applaud you for it. The resulting Sandvox document won't be a copy of your original website - while that would be nice, there are just too many differences between the architecture of an iWeb site and a Sandvox site to make that feasible. Use Sandvox to create and build websites from your Macintosh. Sandvox will go through your published iWeb site, and one page at a time, create new Sandvox pages containing the main text and graphics that it finds on the iWeb source page.Īnd, while it's doing it, you get a spiffy animation to watch! While there is no "magic bullet" to make the process completely automated, our new Site Extractor feature will make the process somewhat easier. Sandvox 2.1.6 helps build sophisticated websites By Adam Berenstain Macworld 10:30 pm PDT At a Glance Expert's Rating Pros Easy to create sites with powerful interactive features. It has been a pretty manual process up until now, requiring each page's content to be copied and pasted from iWeb to Sandvox. With MobileMe shutting down in just two weeks, scores of people are discovering Sandvox and moving over their websites. Or they want a Mac application that can integrate perfectly with an existing Windows Exchange workflow.ĭespite the arrival of Entourage 2008, a "real" Outlook client could be an opportunity for Apple to keep switchers coming as well as give a boost for the Mac in the enterprise.Today we are very proud to announce the availability of the new 2.6 version of Sandvox! However, when you scroll down to the comments underneath the Entourage blog post, many Mac users in an Exchange environment say they want a full Exchange client. Sandvox makes website creation elegant, intuitive and fun. I perceived an ironic twinge as an Office user over the post's title: "It's about time."Ĭheck out the related post: Microsoft’s Mac Business Unit: Love the sinner, hate the sin. We can only hope so, since the last version was released some 4 years ago. The Mac BU team appears to have done many good things to Entourage. The GM was released to manufacturing mid-December, so it will happen on the show floor. Microsoft's Mac Business Unit expects to change this situation with the introduction of Microsoft Office 2008 for Mac at the Macworld Expo in January. Sandvox is for Mac users who want to create a professional looking website quickly and easily. If it's Entourage, it's a shame and there's no good reason why an important app such as Entourage should still be using Rosetta. Doesn't matter much to me, though: my expensive computer bogs terribly as a result. I don't know whether the fault lies with Entourage or with the Apple Rosetta emulation technology on which it runs. Killing the process arrests the inexorable growth of the blue inactive memory. The problem seems to be that the invisible Entourage "Database Daemon" app bleeds memory like a stuck pig. I'm running just a Web browser on a system with 3GB of RAM, and yet I'm down to 16MB free? Super! I rebooted my machine this week, then took a shower when I was done, here's what I saw (note the blue). ![]() Get Started Compare Plans The Best Sandvox Hosting Solution. Almost immediately, however, the blue "inactive" memory slice starts ticking upwards, at a rate of several megabytes per second. Sandvox Hosting 20X FASTER Sandvox Web Hosting Login Sales Chat +1 (734) 222-4678 Cart Hosting WordPress Hosting by Service Products Resources Contact Just 2.99 /mo Sandvox Hosting A2s Sandvox Hosting. Es gratis registrarse y presentar tus propuestas laborales. 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Mögliche Zeiträume für die WWDC23 wären damit die vom 5. Steve Jobs introduces MacBook Air during keynote presentation at Macworld 2008. ![]() During his life, and especially during his time leading Apple, he became iconic for his attention. Test the limits, see where it fails, share in the experience, iterate.Įmbrace the uncertainty of it all and empower your children to develop resilience and a passion for learning. That multiple-use functionality is exactly how late Apple CEO Steve Jobs teased the first iPhone when he introduced it on stage ten years ago today, on Jan. Wann finden die WWDC23 und ihre Keynote statt Die Apple World Wide Developers Conference findet meistens in der erste Juni-Hälfte eines Jahres statt, nicht selten in der ersten vollen Woche des Monats. Apples founder and former CEO, Steve Jobs, died of pancreatic cancer on October 5, 2011. Pretend you’re a filmmaker or a dentist or an international spy. Introducing the all-new Mac Studio and Studio Display, new iPad Air, new iPhone SE, and iPhone 13 and iPhone 13 Pro in two new shades of green. Published + Follow On January 9th, 2007, Steve Jobs, the CEO of Apple Computers, announced a new product that he believed would change his company and industry - the iPhone. ![]() Show them that (1) some tasks may appear complex but are, in fact, totally manageable, and (2) tackling difficult problems in and of itself can be rewarding and worthwhile. In this keynote, Jobs was reaping what Apple’s policy had sowed: Everyone brought their own Wi-Fi based tethering product, and the entire room was swamped. Watch a YouTube "how-to" guide as a team. ![]() I think one of the most important things you can do to ready them for any tech that comes their way is what my parents did for me: nurture their innate curiosity and encourage them to embrace challenge.Ĭonsider working together on a project. Preparing your children for an unpredictable future - with AI and quantum and god knows what else - can be scary. ![]() ![]() ![]() The format of these diptychs characteristically included a depiction of the Madonna and Child on the right panel and a portrait of the diptych’s owner in prayer beside their portrait saint on the left panel. ![]() These pieces typically featured scenes from the Bible, secular portraits, and depictions of the Holy Trinity. ![]() Then from around 1400 to 1580 in Flanders, we see an influx of diptychs in Northern Renaissance religious paintings, which became popular with prominent Flemish artists such as Jan van Eyck. During the Byzantine era, diptychs frequently took their place as traveling icons for private religious purposes.ĭiptychs were widespread in Italy by the 13th century and regularly featured in Italian Renaissance artworks. However, the triptych was a more popular choice for altarpieces. Diptychs could be used as sacred artworks for Christian art, and they were sometimes made into altarpieces. They were commonly hinged together as a means of protecting the artwork encased within. There were luxurious versions, crafted with extravagant materials and standard diptychs with wooden frames.ĭiptychs were a favored art form of Medieval paintings, which continued into the Renaissance period. The plates were often made from wood, but versions made from metal or bone could also be found. Then, as if by magic, heating the wax slightly would smooth it over and it would be good as new, erasing all previous etchings. Where a diptych was made up of a pair of plates that were hinged together and filled with wax that could be inscribed, a stylus was then used to scratch the surface of the wax to write on it.Īn ivory consular diptych of Areobindus, Byzantium (506 AD), located in the Louvre Museum in Paris, France Louvre Museum, Public domain, via Wikimedia Commons Diptychs were used as writing tablets that could fold we can almost think of the diptych as an ancient version of the standard notebook. If we break down the diptych definition, we find that it is derived from the Greek words di meaning “two” and ptychē meaning “fold.” Its original title gives us an indication of its original function. An example of this would be a diptych containing the portraits of a married couple, where each partner was depicted in a separate panel, but the same color palette and technique were used in each panel to provide cohesion. It is also common for the panels to share composition or color but depict different scenes in each panel. The two panels often depict scenes that are closely related to each other or demonstrate different perspectives of the same scene. Adding another panel would transform the diptych into a triptych.ĭiptychs come in a variety of styles. The panels that form diptych artwork can be fixed together by a hinge or they can be adjoining pieces. The formation can be portrait or landscape and it is common for both pieces to be the same size. Diptych artwork can feature paintings, photographs, drawings, carvings, or any flat piece of artwork. Here is the diptych definition, put simply a diptych is an object that is made up of two parts, a singular piece of artwork formed by a pair of panels joined together.
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Its most prominent feature includes a custom timer, hotkeys to change or delete current wallpaper, rename wallpaper and change aero color, etc. WallManager is free to use the software, and you can download it on the Windows platform only. There is also an option to choose multiple folders at the same time which makes it better than others. Simply you need to choose your favorite wallpaper folder, set them as wallpaper, choose a time to change the wallpaper, and that’s it. Its automatic wallpaper changer feature automatically changes wallpaper after a defined time interval. The solution allows you to manage a huge collection of wallpapers easily, create categories, delete duplicate images, and much more. It is one of the best alternatives to Variety Wallpaper Changer and comes with all the leading tools and features to make it a one-stop solution. WallManager is a powerful wallpaper manager that automatically changes background wallpaper. 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Wallpaper Juggler is a free and open-source Windows software that lets you download high-quality wallpapers and change them periodically. Irvue is a cross-platform solution, and you can enjoy its service on Windows and Mac devices only. One of the most interesting facts about this solution is that it automatically downloads and displays wallpapers from Unsplash and other leading platforms. Irvue also can add widgets on your screen like games, calendars, and other stunning things. You can also be able to download and share its wallpapers with others with just a single click. There is also an option to add your custom wallpapers on your screen that randomly change without any limit. It is similar to Variety Wallpaper Changer and offers almost all the leading tools and features to make it better than others. ![]() It is known as a menu bar wallpaper changer and allows you to refresh your desktop wallpaper without distracting from the main work. The software integrates with Unsplash and daily introduces hundreds of stunning wallpapers to make and deliver the best wallpaper solution. Irvue is a Free, Fast, and Open-Source Auto Wallpaper Changer that brings thousands of stunning wallpapers to your screen. ![]() ![]() ![]() The practice of bonsai is sometimes confused with dwarfing, but dwarfing generally refers to research, discovery, or creation of plants that are permanent, genetic miniatures of existing species. Throughout the year, the bonsai is shaped to limit growth, redistribute foliar vigor to areas requiring further development, and meet the artist's detailed design. From that point forward, its growth is restricted by the pot environment. When the candidate bonsai nears its planned final size, it is planted in a display pot, usually one designed for bonsai display in one of a few accepted shapes and proportions. The source specimen is shaped to be relatively small and to meet the aesthetic standards of bonsai, which emphasizes not the entirety of grand sceneries but rather only the tree itself. Some species are popular as bonsai material because they have characteristics, such as small leaves or needles, that make them appropriate for the compact visual scope of bonsai. Bonsai can be created from nearly any perennial woody-stemmed tree or shrub species that produces true branches and can be cultivated to remain small through pot confinement with crown and root pruning. This may be a cutting, seedling, a tree from the wild (known as Yamadori) or small tree of a species suitable for bonsai development. Instead, bonsai practice focuses on long-term cultivation and shaping of one or more small trees growing in a container.Ī bonsai is created beginning with a specimen of source material. By contrast with other plant cultivation practices, bonsai is not intended for production of food or for medicine. Purposes of bonsai are primarily contemplation for the viewer, and the pleasant exercise of effort and ingenuity for the grower. According to Stephen Orr in The New York Times, "the term should be reserved for plants that are grown in shallow containers following the precise tenets of bonsai pruning and training, resulting in an artful miniature replica of a full-grown tree in nature." In the most restrictive sense, "bonsai" refers to miniaturized, container-grown trees adhering to Japanese tradition and principles. ![]() The loanword "bonsai" has become an umbrella term in English, attached to many forms of diminutive potted plants, and also on occasion to other living and non-living things. Similar versions of the art exist in other cultures, including the miniature living landscapes of Vietnamese Hòn non bộ.ĭuring the Tang dynasty, when penjing was at its height, the art was first introduced in China. Penjing and bonsai differ in that the former attempts to display “wilder,” more naturalistic scenes, often representing landscapes, including elements such as water, rocks or figurines on the other hand, bonsai typically focuses on a single tree or a group of trees of the same species, with a higher level of aesthetic refinement. ![]() Bonsai at the National Bonsai & Penjing Museum at the United States National Arboretumīonsai ( Japanese: 盆栽, lit.'tray planting', pronounced ( listen)) is the Japanese and East Asian art of growing and training miniature trees in containers, developed from the traditional Chinese art form of pénjǐng ( 盆景). ![]() ![]() ![]() In 2012, its parliament passed a law requiring internet service providers to block access to websites on a government-maintained blacklist. The Russian government has taken steps to increase its control of the internet in the last decade. Putin nuclear warning: What is DEFCON? What's nuclear deterrence? What to know amid Putin's warning Is Russia’s internet censored? Fourteen journalists have been imprisoned and 58 killed in Russia since the formation of the Russian Federation, according to the Commission to Protect Journalists. Last year, a Russian journalist was jailed for 25 days for a joke retweet authorities determined called for an illegal protest. The European Union voted to ban Russian state-owned media like Russia Today and Sputnik, contending that they have spread disinformation and helped justify Putin's decision to wage war.Īnd Russia has a notorious record against journalists who do work critical of the Kremlin. His show subsequently pulled from the air and did not appear at its regularly scheduled time. Shortly after Putin greenlit the invasion of Ukraine, a prominent Russian TV journalist spoke against the war. 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